Wednesday, July 22, 2015

Human Adipose Derived Mesenchymal Progenitor Cells Used For Cartilage Regeneration

Mesenchymals stem cells, or MSC’s, are known to have the potential for articular cartilage regeneration and are even suggested for the treatment of osteoarthritis (OA). Here we look into a study that was done to investigate whether intra-articular injection of xenogeneic human adipose-derived mesenchymal progenitor cells (haMPC’s) promote articular cartilage repair in rabbit OA model and engrafted into rabbit articular cartilage.

OA was induced surgically by anterior cruciate ligament transection and medical menisectomy of the knee joints. Meanwhile, the haMPC’s were cultured in vitro—phenotypes and differentiation characteristics of cells were then evaluated.

Six weeks after the surgery, hyluric acid (HA) or haMPC’s were injected into the knee joints with the contralateral knee servicing as normal control. All of the rabbits were sacrificed at the sixteenth week after surgery.

Using macroscopic examination, hematoxylin/eoisin and Safrin-O/Fast green staining and immunohistochemistry, assessments were performed. This data revealed that haMPC treatment promoted cartilage repairs. It was also found that signals of human mitochondrial can be directly detected in cartilage treated with haMPC’s.

These results suggest that intra-articular injection of haMPC’s promotes regeneration of articular cartilage in the rabbit OA model, which supports the notion that MPC’s are transplantable between HLA-incompatible individuals. These findings show that the future of regenerative medicine is extremely promising.

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